Characterization of human adipose tissue-derived stromal cells isolated from diabetic patient's distal limbs with critical ischemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F14%3A10293080" target="_blank" >RIV/00216208:11130/14:10293080 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/14:00432936 RIV/00023001:_____/14:00059104

Result on the web

<a href="http://dx.doi.org/10.1002/cbf.3056" target="_blank" >http://dx.doi.org/10.1002/cbf.3056</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cbf.3056" target="_blank" >10.1002/cbf.3056</a>

Result language

angličtina

Original language name

Characterization of human adipose tissue-derived stromal cells isolated from diabetic patient's distal limbs with critical ischemia

Original language description

Adipose tissue is an abundant source of autologous adult stem cells that may bring new therapeutic perspectives on the treatment of diabetes and its complications. It is unclear whether adipose tissue-derived stromal cells (ASCs) of diabetic patients, constantly influenced by hyperglycaemia, have the same properties as non-diabetic controls. As an alternative source of ASCs, adipose tissue from distal limbs of diabetic patients with critical ischemia was isolated. ASCs were characterized in terms of cell surface markers, multilineage differentiation and the expression of vascular endothelial growth factor (VEGFA), chemokine-related genes and compared with non-diabetic controls. Flow cytometry analysis confirmed mesenchymal phenotypes in both diabetic and non-diabetic ASCs. Nevertheless, 40% of diabetic and 20% of non-diabetic ASC samples displayed high expressions of fibroblast marker, which inversely correlated with the expression of CD105. In diabetic patients, significantly decrease

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell Biochemistry and Function

ISSN

0263-6484

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

7

Country of publishing house

DK - DENMARK

Number of pages

8

Pages from-to

597-604

UT code for WoS article

000343798900007

EID of the result in the Scopus database

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