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Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10293988" target="_blank" >RIV/00216208:11130/15:10293988 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985823:_____/15:00444927

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s00429-013-0697-1" target="_blank" >http://dx.doi.org/10.1007/s00429-013-0697-1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00429-013-0697-1" target="_blank" >10.1007/s00429-013-0697-1</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy

  • Original language description

    The effects of tetanus toxin (TeNT) both in the spinal cord, in clinical tetanus, and in the brain, in experimental focal epilepsy, suggest disruption of inhibitory synapses. TeNT is a zinc protease with selectivity for Vesicle Associated Membrane Protein (VAMP; previously synaptobrevin), with a reported selectivity for VAMP2 in rats. We found spatially heterogeneous expression of VAMP1 and VAMP2 in the hippocampus. Inhibitory terminals in stratum pyramidale expressed significantly more VAMP1 than VAMP2, while glutamatergic terminals in stratum radiatum expressed significantly more VAMP2 than VAMP1. Intrahippocampal injection of TeNT at doses that induce epileptic foci cleaved both isoforms in tissue around the injection site. The cleavage was modest at 2 days after injection and more substantial and extensive at 8 and 16 days. Whole-cell recordings from CA1 pyramidal cells close to the injection site, made 8-16 days after injection, showed that TeNT decreases spontaneous EPSC frequenc

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT14489" target="_blank" >NT14489: Understanding of functional organization of temporal lobe epilepsy neuronal networks</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Brain Structure and Function

  • ISSN

    1863-2653

  • e-ISSN

  • Volume of the periodical

    220

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    17

  • Pages from-to

    1013-1029

  • UT code for WoS article

    000350350300025

  • EID of the result in the Scopus database

    2-s2.0-84892404796