Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10293988" target="_blank" >RIV/00216208:11130/15:10293988 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/15:00444927
Result on the web
<a href="http://dx.doi.org/10.1007/s00429-013-0697-1" target="_blank" >http://dx.doi.org/10.1007/s00429-013-0697-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00429-013-0697-1" target="_blank" >10.1007/s00429-013-0697-1</a>
Alternative languages
Result language
angličtina
Original language name
Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy
Original language description
The effects of tetanus toxin (TeNT) both in the spinal cord, in clinical tetanus, and in the brain, in experimental focal epilepsy, suggest disruption of inhibitory synapses. TeNT is a zinc protease with selectivity for Vesicle Associated Membrane Protein (VAMP; previously synaptobrevin), with a reported selectivity for VAMP2 in rats. We found spatially heterogeneous expression of VAMP1 and VAMP2 in the hippocampus. Inhibitory terminals in stratum pyramidale expressed significantly more VAMP1 than VAMP2, while glutamatergic terminals in stratum radiatum expressed significantly more VAMP2 than VAMP1. Intrahippocampal injection of TeNT at doses that induce epileptic foci cleaved both isoforms in tissue around the injection site. The cleavage was modest at 2 days after injection and more substantial and extensive at 8 and 16 days. Whole-cell recordings from CA1 pyramidal cells close to the injection site, made 8-16 days after injection, showed that TeNT decreases spontaneous EPSC frequenc
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14489" target="_blank" >NT14489: Understanding of functional organization of temporal lobe epilepsy neuronal networks</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Brain Structure and Function
ISSN
1863-2653
e-ISSN
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Volume of the periodical
220
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
17
Pages from-to
1013-1029
UT code for WoS article
000350350300025
EID of the result in the Scopus database
2-s2.0-84892404796