Role of Kv7 channels in responses of the pulmonary circulation to hypoxia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10294584" target="_blank" >RIV/00216208:11130/15:10294584 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/15:10294584 RIV/27283933:_____/15:N0000011

Result on the web

<a href="http://dx.doi.org/10.1152/ajplung.00362.2013" target="_blank" >http://dx.doi.org/10.1152/ajplung.00362.2013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1152/ajplung.00362.2013" target="_blank" >10.1152/ajplung.00362.2013</a>

Result language

angličtina

Original language name

Role of Kv7 channels in responses of the pulmonary circulation to hypoxia

Original language description

Hypoxic pulmonary vasoconstriction (HPV) is a beneficial mechanism that diverts blood from hypoxic alveoli to better ventilated areas of the lung, but breathing hypoxic air causes the pulmonary circulation to become hypertensive. Responses to airway hypoxia are associated with depolarization of smooth muscle cells in the pulmonary arteries and reduced activity of K+ channels. As Kv7 channels have been proposed to play a key role in regulating the smooth muscle membrane potential, we investigated their involvement in the development of HPV and hypoxia-induced pulmonary hypertension. Vascular effects of the selective Kv7 blocker, linopirdine, and Kv7 activator, flupirtine, were investigated in isolated, saline-perfused lungs from rats maintained for 3-5days in an isobaric hypoxic chamber (FIO2 = 0.1) or room air. Linopirdine increased vascular resistance in lungs from normoxic, but not hypoxic rats. This effect was associated with reduced mRNA expression of the Kv7.4 channel alpha-subun

Czech name

—

Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

American Journal of Physiology - Lung Cellular and Molecular Physiology

ISSN

1040-0605

e-ISSN

—

Volume of the periodical

308

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

"L48"-"L57"

UT code for WoS article

000347230700005

EID of the result in the Scopus database

2-s2.0-84920260955