Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10294604" target="_blank" >RIV/00216208:11130/15:10294604 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/15:10294604

Result on the web

<a href="http://dx.doi.org/10.3324/haematol.2014.109892" target="_blank" >http://dx.doi.org/10.3324/haematol.2014.109892</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3324/haematol.2014.109892" target="_blank" >10.3324/haematol.2014.109892</a>

Result language

angličtina

Original language name

Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia

Original language description

Juvenile myelomonocytic leukemia is a rare myeloproliferative disease in young children. While hematopoietic stem cell transplantation remains the only curative therapeutic option for most patients, children with juvenile myelomonocytic leukemia increasingly receive novel agents in phase I-II clinical trials as pre-transplant therapy or therapy for relapse after transplantation. However, response criteria or definitions of outcome for standardized evaluation of treatment effect in patients with juvenilemyelomonocytic leukemia are currently lacking. Here we propose criteria to evaluate the response to the non-transplant therapy and definitions of remission status after hematopoietic stem cell transplantation. For the evaluation of non-transplant therapy, we defined 6 clinical variables (white blood cell count, platelet count, hematopoietic precursors and blasts in peripheral blood, bone marrow blast percentage, spleen size and extramedullary disease) and 3 genetic variables (cytogeneti

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Haematologica

ISSN

0390-6078

e-ISSN

—

Volume of the periodical

100

Issue of the periodical within the volume

1

Country of publishing house

IT - ITALY

Number of pages

6

Pages from-to

17-22

UT code for WoS article

000351278500018

EID of the result in the Scopus database

2-s2.0-84920147335