Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10294671" target="_blank" >RIV/00216208:11130/15:10294671 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/15:10294671

Result on the web

<a href="http://dx.doi.org/10.1038/ng.3245" target="_blank" >http://dx.doi.org/10.1038/ng.3245</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/ng.3245" target="_blank" >10.1038/ng.3245</a>

Result language

angličtina

Original language name

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

Original language description

Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions(1,2), finding major pathways contributing to risk(3), with some loci shared across immune disorders(4-6). To make genetic comparisons across autoimmune disorders as informative as possible, a dense genotyping array, the Immunochip, was developed, from which we identified four new T1D-associated regions (P < 5 x 10(-8)). A comparative analysis with 15 immune diseases showed that T1D is more similar genetically to other autoantibody-positive diseases, significantly most similar to juvenile idiopathic arthritis and significantly least similar to ulcerative colitis, and provided support for three additional new T1D risk loci. Using a Bayesian approach, we defined credible sets for the T1D-associated SNPs. The associated SNPs localized to enhancer sequences active in thymus, T and B cells, and CD34(+) stem cells. Enhancer-promoter interactions can now be analyzed in these cell types to identify which particul

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Genetics

ISSN

1061-4036

e-ISSN

—

Volume of the periodical

47

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

381-"U199"

UT code for WoS article

000351922900014

EID of the result in the Scopus database

2-s2.0-84930408328