Combinatorial strategies for the induction of immunogenic cell death

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10294962" target="_blank" >RIV/00216208:11130/15:10294962 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/15:10294962

Result on the web

<a href="http://dx.doi.org/10.3389/fimmu.2015.00187" target="_blank" >http://dx.doi.org/10.3389/fimmu.2015.00187</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2015.00187" target="_blank" >10.3389/fimmu.2015.00187</a>

Result language

angličtina

Original language name

Combinatorial strategies for the induction of immunogenic cell death

Original language description

The term "immunogenic cell death" (ICD) is commonly employed to indicate a peculiar instance of regulated cell death (RCD) that engages the adaptive arm of the immune system. The inoculation of cancer cells undergoing ICD into immunocompetent animals elicits a specific immune response associated with the establishment of immunological memory. Only a few agents are intrinsically endowed with the ability to trigger ICD. These include a few chemotherapeutics that are routinely employed in the clinic, likedoxorubicin, mitoxantrone, oxaliplatin, and cyclophosphamide, as well as some agents that have not yet been approved for use in humans. Accumulating clinical data indicate that the activation of adaptive immune responses against dying cancer cells is associated with improved disease outcome in patients affected by various neoplasms. Thus, novel therapeutic regimens that trigger ICD are urgently awaited. Here, we discuss current combinatorial approaches to convert otherwise non-immunogeni

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Immunology

ISSN

1664-3224

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

24. duben

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

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UT code for WoS article

000354936800001

EID of the result in the Scopus database

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