Gastrointestinal Autoimmunity Associated With Loss of Central Tolerance to Enteric alpha-Defensins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10295542" target="_blank" >RIV/00216208:11130/15:10295542 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/15:00446217 RIV/00064203:_____/15:10295542
Result on the web
<a href="http://dx.doi.org/10.1053/j.gastro.2015.05.009" target="_blank" >http://dx.doi.org/10.1053/j.gastro.2015.05.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1053/j.gastro.2015.05.009" target="_blank" >10.1053/j.gastro.2015.05.009</a>
Alternative languages
Result language
angličtina
Original language name
Gastrointestinal Autoimmunity Associated With Loss of Central Tolerance to Enteric alpha-Defensins
Original language description
BACKGROUND & AIMS: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autoimmune disorder characterized by chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency, but patients also develop intestinal disorders. APECED is an autosomal recessive disorder caused by mutations in the autoimmune regulator (AIRE, which regulates immune tolerance) that allow self-reactive T cells to enter the periphery. Enteric a-defensins are antimicrobial peptides secretedby Paneth cells. Patients with APECED frequently have gastrointestinal symptoms and seroreactivity against secretory granules of Paneth cells. We investigated whether enteric a-defensins are autoantigens in humans and mice with AIRE deficiency. METHODS:We analyzed clinical data, along with serum and stool samples and available duodenal biopsies from 50 patients with APECED collected from multiple centers in Europe. Samples were assessed for expression of defensins and other molecules by
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP302%2F12%2FG101" target="_blank" >GBP302/12/G101: Molecular mechanisms of signaling through leukocyte receptors their role in health and disease.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gastroenterology
ISSN
0016-5085
e-ISSN
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Volume of the periodical
149
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
139-150
UT code for WoS article
000356610400030
EID of the result in the Scopus database
2-s2.0-84931412671