NF-kappa B, p38 MAPK, ERK1/2, mTOR, STAT3 and increased glycolysis regulate stability of paricalcitol/dexamethasone-generated tolerogenic dendritic cells in the inflammatory environment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10296411" target="_blank" >RIV/00216208:11130/15:10296411 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10296411
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546455/" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546455/</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
NF-kappa B, p38 MAPK, ERK1/2, mTOR, STAT3 and increased glycolysis regulate stability of paricalcitol/dexamethasone-generated tolerogenic dendritic cells in the inflammatory environment
Original language description
Tolerogenic dendritic cells (tDCs) may offer an intervention therapy in autoimmune diseases or transplantation. Stable immaturity and tolerogenic function of tDCs after encountering inflammatory environment are prerequisite for positive outcome of immunotherapy. However, the signaling pathways regulating their stable tolerogenic properties are largely unknown. In this study, we demonstrated that human monocyte-derived tDCs established by using paricalcitol (analogue of vitamin D2), dexamethasone and monophosphoryl lipid A exposed for 24h to LPS, cytokine cocktail, polyI:C or CD40L preserved reduced expression of co-stimulatory molecules, increased levels of inhibitory molecules ILT-3, PDL-1 and TIM-3, increased TLR-2, increased secretion of IL-10 and TGF-beta, reduced IL-12 and TNF-alpha secretion and reduced T cell stimulatory capacity. tDCs further induced IL-10-producing T regulatory cells that suppressed the proliferation of responder T cells. In the inflammatory environment, tDCs
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP302%2F10%2F1679" target="_blank" >GAP302/10/1679: Role of innate immunity in the pathogenesis of type I diabetes</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oncotarget
ISSN
1949-2553
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
16
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
14123-14138
UT code for WoS article
000359010000025
EID of the result in the Scopus database
2-s2.0-84931081981