Evaluation of fibrinogen concentrates and prothrombin complex concentrates on coagulation changes in a hypothermic in vitro model using thromboelastometry and thromboelastography
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10315843" target="_blank" >RIV/00216208:11130/15:10315843 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/15:10315843
Result on the web
<a href="http://dx.doi.org/10.3109/00365513.2015.1031694" target="_blank" >http://dx.doi.org/10.3109/00365513.2015.1031694</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/00365513.2015.1031694" target="_blank" >10.3109/00365513.2015.1031694</a>
Alternative languages
Result language
angličtina
Original language name
Evaluation of fibrinogen concentrates and prothrombin complex concentrates on coagulation changes in a hypothermic in vitro model using thromboelastometry and thromboelastography
Original language description
Background. Hypothermic coagulopathy is very challenging in bleeding trauma patients. Therefore, we decided to evaluate the efficacy of fibrinogen and prothrombin complex in 30 degrees C hypothermia in vitro to investigate if higher levels of fibrinogenand prothrombin complex concentrate can compensate for the hypothermic effect on coagulation as measured by thromboelastometry/thromboelastography. Methods. Blood samples were obtained from 12 healthy volunteers (six men and six women) in our study. Measurements were performed at 37 degrees C and 30 degrees C simultaneously, then at 30 degrees C with adding fibrinogen and prothrombin complex and in the last step samples with added coagulation factors were warmed back to 37 degrees C. Results. We found that 30 degrees C hypothermic coagulopathy can be detected both by thromboelastometry and thromboelastography. Hypothermic coagulopathy can be restored by fibrinogen to the point where the results do not significantly differ from 37 degree
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scandinavian Journal of Clinical and Laboratory Investigation
ISSN
0036-5513
e-ISSN
—
Volume of the periodical
75
Issue of the periodical within the volume
5
Country of publishing house
NO - NORWAY
Number of pages
8
Pages from-to
407-414
UT code for WoS article
000360177600009
EID of the result in the Scopus database
2-s2.0-84933503106