Nitric oxide as an indicator for severity of injury in polytrauma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F16%3A10323839" target="_blank" >RIV/00216208:11130/16:10323839 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/16:10323839
Result on the web
<a href="http://dx.doi.org/10.4149/BLL_2016_041" target="_blank" >http://dx.doi.org/10.4149/BLL_2016_041</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2016_041" target="_blank" >10.4149/BLL_2016_041</a>
Alternative languages
Result language
angličtina
Original language name
Nitric oxide as an indicator for severity of injury in polytrauma
Original language description
BACKGROUND: Patients with injuries to multiple organs or organ systems are in a serious risk of shock, multiorgan failure and death. Although there are scoring systems available to assess the extent of polytrauma and guide the prognosis, their usefulness is limited by their considerably subjective nature. As the production of nitric oxide (NO) by many cell types is elevated in tissue injury, we hypothesized that serum concentration of NO (and its oxidation products, NOx) represents a suitable marker of polytrauma correlating with prognosis. We wanted to prove that nitric oxide could serve as an indicator for severity of injury in polytrauma. METHODS: We measured serum NOx and standard biochemical parameters in 93 patients with various degrees of polytrauma, 15 patients with minor injuries and 20 healthy volunteers. RESULTS: On admission, serum NOx was higher in patients with moderate polytrauma than both in controls and patients with minor injury, and it was even higher in patients with severe polytrauma. Surprisingly, NOx on admission was normal in the group of patients that required cardiopulmonary resuscitation or died within 48 hours after admission. In the groups, where it was elevated on admission, serum NOx dropped to normal values within 12 hours. Blood lactate levels on admission were elevated in proportion to the severity of subsequent clinical course. CONCLUSION: Elevated serum NOx and blood lactate in patients with polytrauma are markers of serious clinical course, while normal NOx combined with a very high lactate may signal a fatal prognosis (Fig. 4, Ref. 8). Text in PDF www.elis.sk.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GA13-01710S" target="_blank" >GA13-01710S: Vascular reactivity in pulmonary hypertension</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bratislavské lekárske listy
ISSN
0006-9248
e-ISSN
—
Volume of the periodical
117
Issue of the periodical within the volume
4
Country of publishing house
SK - SLOVAKIA
Number of pages
4
Pages from-to
217-220
UT code for WoS article
000374429300006
EID of the result in the Scopus database
2-s2.0-85014823941