Comparative analysis of speech impairment and upper limb motor dysfunction in Parkinson's disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10358963" target="_blank" >RIV/00216208:11130/17:10358963 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21230/17:00309931 RIV/68407700:21460/17:00309931 RIV/00064203:_____/17:10358963 RIV/00216208:11110/17:10358963 RIV/00064165:_____/17:10358963

Result on the web

<a href="http://dx.doi.org/10.1007/s00702-016-1662-y" target="_blank" >http://dx.doi.org/10.1007/s00702-016-1662-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-016-1662-y" target="_blank" >10.1007/s00702-016-1662-y</a>

Result language

angličtina

Original language name

Comparative analysis of speech impairment and upper limb motor dysfunction in Parkinson's disease

Original language description

It is currently unknown whether speech and limb motor effectors in Parkinson&apos;s disease (PD) are controlled by similar underlying brain processes. Based on computerized objective analysis, the aim of this study was to evaluate potential correlation between speech and mechanical tests of upper limb motor function. Speech and upper limb motor tests were performed in 22 PD patients and 22 healthy controls. Quantitative acoustic analyses of eight key speech dimensions of hypokinetic dysarthria, including quality of voice, sequential motion rates, consonant articulation, vowel articulation, average loudness, loudness variability, pitch variability, and number of pauses, were performed. Upper limb movements were assessed using the motor part of the Unified Parkinson&apos;s Disease Rating Scale, contactless three-dimensional motion capture system, blinded expert evaluation, and the Purdue Pegboard Test. Significant relationships were observed between the quality of voice assessed by jitter and amplitude decrement of finger tapping (r = 0.61, p = 0.003), consonant articulation evaluated using voice onset time and expert rating of finger tapping (r = 0.60, p = 0.003), and number of pauses and Purdue Pegboard Test score (r = 0.60, p = 0.004). The current study supports the hypothesis that speech impairment in PD shares, at least partially, similar pathophysiological processes with limb motor dysfunction. Vocal fold vibration irregularities appeared to be influenced by mechanisms similar to amplitude decrement during repetitive limb movements. Consonant articulation deficits were associated with decreased manual dexterity and movement speed, likely reflecting fine motor control involvement in PD.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

—

Volume of the periodical

124

Issue of the periodical within the volume

4

Country of publishing house

AT - AUSTRIA

Number of pages

8

Pages from-to

463-470

UT code for WoS article

000398517500007

EID of the result in the Scopus database

2-s2.0-85001544970