Sequential Burkholderia cenocepacia Isolates from Siblings with Cystic Fibrosis Show Increased Lung Cell Attachment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373194" target="_blank" >RIV/00216208:11130/17:10373194 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/17:10373194

Result on the web

<a href="https://doi.org/10.1164/rccm.201607-1360LE" target="_blank" >https://doi.org/10.1164/rccm.201607-1360LE</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1164/rccm.201607-1360LE" target="_blank" >10.1164/rccm.201607-1360LE</a>

Result language

angličtina

Original language name

Sequential Burkholderia cenocepacia Isolates from Siblings with Cystic Fibrosis Show Increased Lung Cell Attachment

Original language description

Burkholderia cepacia complex (Bcc) is a group of 20 genetically distinct bacterial species (1) that has a severe impact on the quality of life of people with cystic fibrosis (CF) and is associated with a more rapid decline of lung function than Pseudomonas aeruginosa (2). B. cenocepacia is the most virulent species within the Bcc and is most frequently associated with septicemia, although other Bcc species have also been linked to bloodstream infections (BSI) (2, 3). Many pathogens alter their phenotype during chronic infection in response to changing selection pressures, coinfecting species, and antimicrobial therapies (4, 5). Studies on bacterial adaptation in the CF context have predominantly focused on P. aeruginosa; however, the adaptive strategies of B. cenocepacia isolates have also been examined (4, 6, 7). Antimicrobial resistance, loss of motility, tolerance of iron limitation, and increased virulence to host cells over time of chronic infection were reported. In contrast, P. aeruginosa and another member of the Bcc, B. multivorans, showed reduced virulence over time of infection (5, 8). We have examined two series of sequential isolates from two adult male siblings with CF (referred to as P1 and P2). Both patients became infected with Bcc during their teens and were chronically infected when transitioning to adult care.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

American Journal of Respiratory and Critical Care Medicine

ISSN

1073-449X

e-ISSN

—

Volume of the periodical

195

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

832-835

UT code for WoS article

000396640500020

EID of the result in the Scopus database

2-s2.0-85015957945