Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A6241" target="_blank" >RIV/00064203:_____/10:6241 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/10:6241

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence

Original language description

Burkholderia cepacia complex (Bcc) bacteria have gained notoriety as pathogens in cystic fibrosis (CF) because they are difficult to identify and treat and have the ability to spread between CF individuals. Of the 17 formally named species within the complex, Burkholderia cenocepacia dominate in CF, with highly transmissible strains such as the ET-12 (ST-28) and Czech strain (ST-32). The majority of research on the molecular pathogenesis of Bcc bacteria has focused on B. cenocepacia ET-12 epidemic lineage, with gene mutation, genome sequence analysis and most recently global gene expression studies shedding considerable light on the virulence and antimicrobial resistance of this pathogen. These studies demonstrate that the ability of B. cenocepacia toacquire foreign DNA, regulate gene expression, compete for iron during infection, and mediate antimicrobial resistance via its polysaccharides, are key features that underpin the virulence of different strains.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

<a href="/en/project/NS10543" target="_blank" >NS10543: Molecular identification of bacterial strains which cause severe epidemics in Czech patients with cystic fibrosis and prevention of their spread within this population</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Microbiology and Infection

ISSN

1198-743X

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

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UT code for WoS article

000278645700004

EID of the result in the Scopus database

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