Musculoskeletal system in children and adolescents with inflammatory bowel disease: normal muscle force, decreased trabecular bone mineral density and low prevalence of vertebral fractures

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373722" target="_blank" >RIV/00216208:11130/17:10373722 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/17:10373722

Result on the web

<a href="https://doi.org/10.1007/s00431-017-2988-7" target="_blank" >https://doi.org/10.1007/s00431-017-2988-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00431-017-2988-7" target="_blank" >10.1007/s00431-017-2988-7</a>

Result language

angličtina

Original language name

Musculoskeletal system in children and adolescents with inflammatory bowel disease: normal muscle force, decreased trabecular bone mineral density and low prevalence of vertebral fractures

Original language description

Low bone mineral density (BMD) and an increased fracture incidence are two extraintestinal complications associated with inflammatory bowel disease (IBD). We aimed to evaluate musculoskeletal traits and assess vertebral fracture (VF) rate in children and adolescents with IBD. Seventy patients with IBD with a median age of 13.8 years were included. The BMD and geometric parameters of the non-dominant tibia were assessed using pQCT. Dynamic muscle functions were evaluated using jumping mechanography. VFs were assessed according to the semiquantitative standardized method by Genant. The muscle functions adjusted for the patients&apos; weight did not differ from the reference population. A low trabecular BMD (Z-score - 1.6; p &lt; 0.001) and cortical thickness (Z-score - 0.7; p &lt; 0.001) were found in children and adolescents with IBD. Conversely, an increased cortical BMD (Z-score 1.1; p &lt; 0.001) was noted. No significant association was found between the 25-OHD serum levels and the bone or muscle measurements. One patient with asymptomatic VF was identified. Conclusion: IBD in childhood or adolescents affects bones but not muscles. Bone changes are independent of the 25-OHD serum level. A thoracolumbar spine X-ray should not be routinely recommended in children with IBD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30209 - Paediatrics

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Pediatrics

ISSN

0340-6199

e-ISSN

—

Volume of the periodical

176

Issue of the periodical within the volume

10

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

1355-1363

UT code for WoS article

000410752800008

EID of the result in the Scopus database

2-s2.0-85028333344