Muscle functions and bone strength are impaired in adolescents with type 1 diabetes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10375420" target="_blank" >RIV/00216208:11130/18:10375420 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11320/18:10375420 RIV/00064203:_____/18:10375420
Result on the web
<a href="https://doi.org/10.1016/j.bone.2017.10.005" target="_blank" >https://doi.org/10.1016/j.bone.2017.10.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bone.2017.10.005" target="_blank" >10.1016/j.bone.2017.10.005</a>
Alternative languages
Result language
angličtina
Original language name
Muscle functions and bone strength are impaired in adolescents with type 1 diabetes
Original language description
Background: Sarcopenia and osteoporosis are among the late complications of type 1 diabetes (T1D) in adults. Whether and to what extent musculoskeletal impairment is present in childhood and adolescence has yet to be determined. The aim of this study was to assess volumetric bone mineral density (BMD) and dynamic muscle function in adolescents with T1D and to assess the clinical and biochemical predictors of their musculoskeletal system. Methods: Ninety-five children and adolescents (59 boys and 36 girls, mean age 16.2 +/- 1.2 years) with T1D were included in this cross-sectional study. Study participants were divided into two groups according to the duration of the disease (<6 years and >9 years, respectively). Volumetric BMD of the non-dominant tibia was assessed using peripheral quantitative computed tomography (pQCT). Dynamic muscle function was evaluated using jumping mechanography. Gender- and height-specific Z-scores were calculated using published reference data. HbA1c was evaluated retrospectively as an average over the past 5 years. Results: Relative muscle power (P-max/mass) and force (F-max/body weight) were significantly decreased in T1D subjects (mean Z-scores -0.4 +/- 1.0; p < 0.001, and -03 +/- 1.1; p < 0.01, respectively). The duration of T1D negatively affected Pmax/mass (p < 0.01) but not Fmax/body weight (p = 0.54). Patients with T1D had also decreased trabecular BMD, the Strength-Strain Index and cortical thickness (mean Z-scores -0.8 +/- 1.3; -0.5 +/- 0.8 and -1.1 0.8, respectively, p < 0.001 for all) whereas cortical BMD was increased when compared to controls (Z-score 12 +/- 0.90, p < 0.001). No association was observed between the HbA1c and 25-hydroxyvitamin D levels and bone or muscle parameters. Conclusion: T1D influences the musculoskeletal system in adolescence. Decreased muscle function could contribute to the osteoporosis reported in adult diabetic patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bone
ISSN
8756-3282
e-ISSN
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Volume of the periodical
106
Issue of the periodical within the volume
January
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
22-27
UT code for WoS article
000417552200003
EID of the result in the Scopus database
2-s2.0-85030988212