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Real-life GH dosing patterns in children with GHD, TS or born SGA: a report from the NordiNet (R) International Outcome Study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373787" target="_blank" >RIV/00216208:11130/17:10373787 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064203:_____/17:10373787

  • Result on the web

    <a href="https://doi.org/10.1530/EJE-16-1055" target="_blank" >https://doi.org/10.1530/EJE-16-1055</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1530/EJE-16-1055" target="_blank" >10.1530/EJE-16-1055</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Real-life GH dosing patterns in children with GHD, TS or born SGA: a report from the NordiNet (R) International Outcome Study

  • Original language description

    Objective: To describe real-life dosing patterns in children with growth hormone deficiency (GHD), born small for gestational age (SGA) or with Turner syndrome (TS) receiving growth hormone (GH) and enrolled in the NordiNet International Outcome Study (IOS; NCT00960128) between 2006 and 2016. Design: This non-interventional, multicentre study included paediatric patients diagnosed with GHD (isolated (IGHD) or multiple pituitary hormone deficiency (MPHD)), born SGA or with TS and treated according to everyday clinical practice from the Czech Republic (IGHD/MPHD/SGA/TS: n = 425/61/316/119), France (n = 1404/188/970/206), Germany (n = 2603/351/1387/411) and the UK (n = 259/60/87/35). Methods: GH dosing was compared descriptively across countries and indications. Proportions of patients by GH dose group (low/medium/high) or GH dose change (decrease/increase/no change) during years 1 and 2 were also evaluated across countries and indications. Results: In the Czech Republic, GH dosing was generally within recommended levels. In France, average GH doses were higher for patients with IGHD, MPHD and SGA than in other countries. GH doses in TS tended to be at the lower end of the recommended label range, especially in Germany and the UK; the majority of patients were in the low-dose group. A significant inverse association between baseline height standard deviation score and GH dose was shown (P &lt; 0.05); shorter patients received higher doses. Changes in GH dose, particularly increases, were more common in the second (40%) than in the first year (25%). Conclusions: GH dosing varies considerably across countries and indications. In particular, almost half of girls with TS received GH doses below practice guidelines and label recommendations.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Journal of Endocrinology

  • ISSN

    0804-4643

  • e-ISSN

  • Volume of the periodical

    177

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    11

  • Pages from-to

    145-155

  • UT code for WoS article

    000406480700010

  • EID of the result in the Scopus database

    2-s2.0-85023209241