Traditional Risk Factors of Acute Coronary Syndrome in Four Different Male Populations - Total Cholesterol Value Does Not Seem To Be Relevant Risk Factor

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373902" target="_blank" >RIV/00216208:11130/17:10373902 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/17:10373902 RIV/00023001:_____/17:00060313

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/66/66_S121.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/66/66_S121.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Traditional Risk Factors of Acute Coronary Syndrome in Four Different Male Populations - Total Cholesterol Value Does Not Seem To Be Relevant Risk Factor

Original language description

Cardiovascular diseases are the most common cause of mortality and morbidity in most populations. As the traditional modifiable risk factors (smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity) were defined decades ago, we decided to analyze recent data in patients who survived acute coronary syndrome (ACS). The Czech part of the study included data from 999 males, and compared them with the post-MONICA study (1,259 males, representing general population). The Lithuanian study included 479 male patients and 456 age-matched controls. The Kazakhstan part included 232 patients and 413 controls. In two countries, the most robust ACS risk factor was smoking (OR 3.85 in the Czech study and 5.76 in the Lithuanian study), followed by diabetes (OR 2.26 and 2.07) and hypertension (moderate risk elevation with OR 1.43 and 1.49). These factors did not influence the ACS risk in Kazakhstan. BMI had no significant effect on ACS and plasma cholesterol was surprisingly significantly lower (P&lt;0.001) in patients than in controls in all countries (4.80 +/- 1.11 vs. 5.76 +/- 1.06 mmol/l in Czechs; 5.32 +/- 1.32 vs. 5.71 +/- 1.08 mmol/l in Lithuanians; 4.88 +/- 1.05 vs. 5.38 +/- 1.13 mmol/l in Kazakhs/Russians). Results from our study indicate substantial heterogeneity regarding major CVD risk factors in different populations with the exception of plasma total cholesterol which was inversely associated with ACS risk in all involved groups. These data reflect ethnical and geographical differences as well as changing pattern of cardiovascular risk profiles.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

66

Issue of the periodical within the volume

Supplement 1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

"S121"-"S128"

UT code for WoS article

000398620900014

EID of the result in the Scopus database

2-s2.0-85017129263