Effects of Increased Myocardial Tissue Concentration of Myristic, Palmitic and Palmitoleic Acids on the Course of Cardiac atrophy of the Failing Heart Unloaded by Heterotopic Transplantation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10375355" target="_blank" >RIV/00216208:11130/18:10375355 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/18:00076569

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/67/67_13.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/67/67_13.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effects of Increased Myocardial Tissue Concentration of Myristic, Palmitic and Palmitoleic Acids on the Course of Cardiac atrophy of the Failing Heart Unloaded by Heterotopic Transplantation

Original language description

The present experiments were performed to evaluate if increased heart tissue concentration of fatty acids, specifically myristic, palmitic and palmitoleic acids that are believed to promote physiological heart growth, can attenuate the progression of unloading-induced cardiac atrophy in rats with healthy and failing hearts. Heterotopic abdominal heart transplantation (HTx) was used as a model for heart unloading. Cardiac atrophy was assessed from the ratio of the native-to-transplanted heart weight (HW). The degree of cardiac atrophy after HTx was determined on days 7, 14, 21 and 28 after HTx in recipients of either healthy or failing hearts. HTx of healthy hearts resulted in 23 +/- 3, 46 +/- 3, 48 +/- 4 and 46 +/- 4 % HW loss at the four time-points. HTx of the failing heart resulted in even greater HW losses, of 46 +/- 4, 58 +/- 3, 66 +/- 2 and 68 +/- 4 %, respectively (P &lt; 0.05). Activation of &quot;fetal gene cardiac program&quot; (e.g. beta myosin heavy chain gene expression) and &quot;genes reflecting cardiac remodeling&quot; (e.g. atrial natriuretic peptide gene expression) after HTx was greater in failing than in healthy hearts (P &lt; 0.05 each time). Exposure to isocaloric high sugar diet caused significant increases in fatty acid concentrations in healthy and in failing hearts. However, these increases were not associated with any change in the course of cardiac atrophy, similarly in healthy and post-HTx failing hearts. We conclude that increasing heart tissue concentrations of the fatty acids allegedly involved in heart growth does not attenuate the unloading-induced cardiac atrophy.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30105 - Physiology (including cytology)

Project

<a href="/en/project/NV16-27420A" target="_blank" >NV16-27420A: New approaches for the prevention of cardiac atrophy: studies in rat model heterotopically transplanted heart</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

67

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

18

Pages from-to

13-30

UT code for WoS article

000426589900002

EID of the result in the Scopus database

2-s2.0-85042783108