A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10375366" target="_blank" >RIV/00216208:11130/18:10375366 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/18:10375366
Result on the web
<a href="https://doi.org/10.1016/j.cell.2018.01.038" target="_blank" >https://doi.org/10.1016/j.cell.2018.01.038</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cell.2018.01.038" target="_blank" >10.1016/j.cell.2018.01.038</a>
Alternative languages
Result language
angličtina
Original language name
A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases
Original language description
While the preponderance of morbidity and mortality in medulloblastoma patients are due to metastatic disease, most research focuses on the primary tumor due to a dearth of metastatic tissue samples and model systems. Medulloblastoma metastases are found almost exclusively on the leptomeningeal surface of the brain and spinal cord; dissemination is therefore thought to occur through shedding of primary tumor cells into the cerebrospinal fluid followed by distal re-implantation on the leptomeninges. We present evidence for medulloblastoma circulating tumor cells (CTCs) in therapy-naive patients and demonstrate in vivo, through flank xenografting and parabiosis, that medulloblastoma CTCs can spread through the blood to the leptomeningeal space to form leptomeningeal metastases. Medulloblastoma leptomeningeal metastases express high levels of the chemokine CCL2, and expression of CCL2 in medulloblastoma in vivo is sufficient to drive leptomeningeal dissemination. Hematogenous dissemination of medulloblastoma offers a new opportunity to diagnose and treat lethal disseminated medulloblastoma.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell
ISSN
0092-8674
e-ISSN
—
Volume of the periodical
172
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
1050-1062
UT code for WoS article
000425937100015
EID of the result in the Scopus database
2-s2.0-85042368937