Novel model of triple-negative breast cancer produces viable circulating tumor cells and rapid lung metastasis for functional testing <i>in vivo</i>
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F23%3AA2402NK6" target="_blank" >RIV/61988987:17110/23:A2402NK6 - isvavai.cz</a>
Result on the web
<a href="https://www.webofscience.com/wos/woscc/full-record/WOS:001153517100003" target="_blank" >https://www.webofscience.com/wos/woscc/full-record/WOS:001153517100003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2023_230404N185" target="_blank" >10.4149/neo_2023_230404N185</a>
Alternative languages
Result language
angličtina
Original language name
Novel model of triple-negative breast cancer produces viable circulating tumor cells and rapid lung metastasis for functional testing <i>in vivo</i>
Original language description
Breast cancer metastases are the main reason for women ' s highest cancer mortality. Even though tumor cell dissemination via circulating tumor cells (CTC) released from the primary site is a very ineffective process, distant metastases appear in 46% of triple-negative breast cancer (TNBC) patients corresponding to the disease aggressiveness. Laboratory models for functional testing which mimic the spread of metastatic cells are needed for efficient investigation of the underlying mechanisms and therapeutic intervention. Here, we describe novel isogenic variants LMC3 and CTC3 of human TNBC cell line MDA-MB-231 that were derived by repeated injection of tumor cells into the tail vein of immunodeficient mice and subsequent selection of metastatic cells from lung metastases. These variants have increased migration potential, altered expression profiles, and elevated tumorigenic potential. Moreover, cell line CTC3 readily produces metastases in the lungs and bone marrow and detectable viable circulating tumor cells in the blood. This model enables rapid and cost-efficient strategies for biomarker exploration and novel intervention approaches to limit the CTC presence in the blood and hence tumor dissemination.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
NEOPLASMA
ISSN
0028-2685
e-ISSN
1338-4317
Volume of the periodical
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Issue of the periodical within the volume
4
Country of publishing house
SK - SLOVAKIA
Number of pages
12
Pages from-to
514-525
UT code for WoS article
001153517100003
EID of the result in the Scopus database
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