Paclitaxel-Loaded Polylactide/Polyethylene Glycol Fibers with Long-Term Antitumor Activity as a Potential Drug Carrier for Local Chemotherapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10376154" target="_blank" >RIV/00216208:11130/18:10376154 - isvavai.cz</a>

Alternative codes found

RIV/61389013:_____/18:00490387 RIV/00216208:11310/18:10376154 RIV/00064203:_____/18:10376154

Result on the web

<a href="https://doi.org/10.1002/mabi.201800011" target="_blank" >https://doi.org/10.1002/mabi.201800011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mabi.201800011" target="_blank" >10.1002/mabi.201800011</a>

Result language

angličtina

Original language name

Paclitaxel-Loaded Polylactide/Polyethylene Glycol Fibers with Long-Term Antitumor Activity as a Potential Drug Carrier for Local Chemotherapy

Original language description

Local application of anticancer agents prolongs the presence time and increases the concentration of drug in the target place and therefore may reduce serious side effects compared to drug systemic administration. The preparation of fibrous materials of polylactide (PLA) and polyethylene glycol (PEG) loaded with paclitaxel (PTX, 1 or 10 wt%) is presented. Scanning electron microscopy proves that PTX is homogeneously incorporated into the fibers. The addition of PEG of various molecular weights (6, 20, or 35 kDa) ensures the release of significantly higher amounts of hydrophobic PTX in a prolonged release time compared to the fibers containing PTX only. Present PLA-PEG fibrous carriers can serve as a drug depot for PTX since they exhibit significant toxicity for cancer cell lines in several-day experiment. They are promising for local recurrence therapy, where the initial release is efficient to kill tumor cells and continued release can prevent their subsequent proliferation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Macromolecular Bioscience

ISSN

1616-5187

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

13

Pages from-to

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UT code for WoS article

000435279400002

EID of the result in the Scopus database

2-s2.0-85045893254