Polylactide/polyethylene glycol fibrous mats for local paclitaxel delivery: comparison of drug release into liquid medium and to HEMA-based hydrogel model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00507853" target="_blank" >RIV/61389013:_____/19:00507853 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/19:10402177
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00706-019-02469-5" target="_blank" >https://link.springer.com/article/10.1007%2Fs00706-019-02469-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-019-02469-5" target="_blank" >10.1007/s00706-019-02469-5</a>
Alternative languages
Result language
angličtina
Original language name
Polylactide/polyethylene glycol fibrous mats for local paclitaxel delivery: comparison of drug release into liquid medium and to HEMA-based hydrogel model
Original language description
2-Hydroxyethyl methacrylate (HEMA) hydrogels containing 37% water were prepared to investigate the release of hydrophobic anticancer drug paclitaxel (PTX) from electrospun polylactide (PLA) fibrous mats. The impact of the incorporated amphiphilic polyethylene glycol (PEG) on the drug release was also studied. The release profiles were investigated in various arrangements and compared to release into aqueous media. The nanofibers with added PEG released significantly higher amounts of paclitaxel and for longer time period compared to fibers containing only the hydrophobic drug. When compared various release conditions, significantly higher amount of paclitaxel released to hydrogel compared to aqueous media. HEMA-based hydrogel was found to better approximate in vivo conditions in comparison with commonly used liquid media.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Monatshefte fur Chemie
ISSN
0026-9247
e-ISSN
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Volume of the periodical
150
Issue of the periodical within the volume
9
Country of publishing house
AT - AUSTRIA
Number of pages
6
Pages from-to
1691-1696
UT code for WoS article
000482907600019
EID of the result in the Scopus database
2-s2.0-85070673101