Health-related quality of life, neuropsychiatric symptoms and structural brain changes in clinically isolated syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10377870" target="_blank" >RIV/00216208:11130/18:10377870 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/18:10377870
Result on the web
<a href="https://doi.org/10.1371/journal.pone.0200254" target="_blank" >https://doi.org/10.1371/journal.pone.0200254</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0200254" target="_blank" >10.1371/journal.pone.0200254</a>
Alternative languages
Result language
angličtina
Original language name
Health-related quality of life, neuropsychiatric symptoms and structural brain changes in clinically isolated syndrome
Original language description
Background Neuropsychiatric symptoms and reduced health-related quality of life (HRQoL) are frequent in multiple sclerosis, where are associated with structural brain changes, but have been less studied in clinically isolated syndrome (CIS). Objective To characterize HRQoL, neuropsychiatric symptoms (depressive symptoms, anxiety, apathy and fatigue), their interrelations and associations with structural brain changes in CIS. Methods Patients with CIS (n = 67) and demographically matched healthy controls (n = 46) underwent neurological and psychological examinations including assessment of HRQoL, neuropsychiatric symptoms and cognitive functioning, and MRI brain scan with global, regional and lesion load volume measurement. Results The CIS group had more, mostly mild, depressive symptoms and anxiety, and lower HRQoL physical and social subscores (p <= 0.037). Neuropsychiatric symptoms were associated with most HRQoL subscores (beta <=-0.34, p <= 0.005). Cognitive functioning unlike clinical disability was associated with depressive symptoms and lower HRQoL emotional subscores (beta <=-0.29, p <= 0.019). Depressive symptoms and apathy were associated with right temporal, left insular and right occipital lesion load (beta >= 0.29, p >= 0.032). Anxiety was associated with lower white matter volume (beta = -0.25, p = 0.045). Conclusion Mild depressive symptoms and anxiety with decreased HRQoL are present in patients with CIS. Neuropsychiatric symptoms contributing to decreased HRQoL are the result of structural brain changes and require complex therapeutic approach in patients with CIS.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/NT12385" target="_blank" >NT12385: Monitoring of MxA mRNA Expression as a Marker of Rresponse to Interferon ß Therapy in Patients with Multiple Sclerosis.</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS One
ISSN
1932-6203
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
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UT code for WoS article
000437809500085
EID of the result in the Scopus database
2-s2.0-85049519777