The enigmatic thymic myoid cells - their 130 years of history, embryonic origin, function and clinical significance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F19%3A10394321" target="_blank" >RIV/00216208:11130/19:10394321 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1alIGBxpN5" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1alIGBxpN5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11756-019-00214-1" target="_blank" >10.2478/s11756-019-00214-1</a>

Result language

angličtina

Original language name

The enigmatic thymic myoid cells - their 130 years of history, embryonic origin, function and clinical significance

Original language description

Thymic myoid cells form a part of the cellular microenvironment of the thymic medulla in fish, amphibians, reptiles, birds, and mammals, including humans. In lower vertebrates they resemble skeletal muscle fibers at the level of light and electron microscopy, in humans they are less noticable even though they contain proteins typically found in the muscle tissue including desmin, actin, acetylcholine receptor, myosin, troponin or myogenic transcription factor. Despite the discovery of thymic myoid cells by German histologist Sigmund Mayer employed at the Charles-Ferdinand University (now Charles University) in Prague, Czech Republic, occurred exactly 130 years ago, as of today, these cells have been mentioned neither in most of the histology textbooks, nor in the histological nomenclature Terminologia Histologica. Thus, we find it appropriate to call these cells &quot;enigmatic.&quot; In this narrative review, we focus on the historical background of the discovery of thymic myoid cells, and current opinions on their embryonic origin and functional significance during the maturation of T-lymphocytes within the thymus. Finally, we present the overview of the clinical importance of this cell population, including the notion of rare mediastinal rhabdomyomas and rhabdomyosarcomas probably originating from these cells. We also ponder over the possible connection between thymic myoid cells and the pathogenesis of autoimmune disease - myasthenia gravis.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30502 - Other medical science

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biologia

ISSN

0006-3088

e-ISSN

—

Volume of the periodical

74

Issue of the periodical within the volume

5

Country of publishing house

SK - SLOVAKIA

Number of pages

11

Pages from-to

521-531

UT code for WoS article

000464768400012

EID of the result in the Scopus database

2-s2.0-85062032354