The effect of poly-ϵ-caprolactone nanofibers with platelets on cell proliferation and viability
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F19%3A10410320" target="_blank" >RIV/00216208:11130/19:10410320 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/19:10394633
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The effect of poly-ϵ-caprolactone nanofibers with platelets on cell proliferation and viability
Original language description
Platelets are effective source of growth factors and other bioactive molecules. They can be combined with an appropriate scaffold where the mechanical properties of the scaffold and bioactive properties of platelets modulate cell behavior in the site of the injury. In this study, we compared different concentrations of platelets adhered on PCL nanofibers and evaluated their effect on mouse 3T3 fibroblasts. Platelets in maximum concentration significantly stimulated the viability when it is compared with control. Proliferation of fibroblasts was significantly higher than in the control group cultured on the plain scaffolds. Cells were well- spread on the scaffolds with adhered platelets, whereas on the plain scaffolds, the cells created clusters. The effect of platelets was dose-dependent. It is obvious, that the combination of bioactive substances and PLC nanofibres significantly stimulates cells growth and metabolic activity of the tested cell type.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/NV17-32285A" target="_blank" >NV17-32285A: Functionalized nanofibers for prevention of incisional hernia formation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
10th Anniversary International Conference on Nanomaterials - Research and Application, NANOCON 2018
ISBN
978-80-87294-89-5
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
477-482
Publisher name
TANGER LTD
Place of publication
SLEZSKA
Event location
Brno
Event date
Oct 17, 2018
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000513131900083