Alcohol septal ablation in patients with severe septal hypertrophy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10399169" target="_blank" >RIV/00216208:11130/20:10399169 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/20:10399169
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=acYbZtFzT9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=acYbZtFzT9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/heartjnl-2019-315422" target="_blank" >10.1136/heartjnl-2019-315422</a>
Alternative languages
Result language
angličtina
Original language name
Alcohol septal ablation in patients with severe septal hypertrophy
Original language description
Objective: The current guidelines suggest alcohol septal ablation (ASA) is less effective in hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular hypertrophy, despite acknowledging that systematic data are lacking. Therefore, we analysed patients in the Euro-ASA registry to test this statement. Methods: We compared the short-term and long-term outcomes of patients with basal interventricular septum (IVS) thickness <30 mm Hg to those with >=30 mm Hg treated using ASA in nine European centres. Results: A total of 1519 patients (57+-14 years, 49% women) with symptomatic HOCM were treated, including 67 (4.4%) patients with IVS thickness >=30 mm. The occurrence of short-term major adverse events were similar in both groups. The mean follow-up was 5.4+-4.3 years and 5.1+-4.1 years, and the all-cause mortality rate was 2.57 and 2.94 deaths per 100 person-years of follow-up in the IVS <30 mm group and the IVS >=30 mm group (p=0.047), respectively. There were no differences in dyspnoea (New York Heart Association class III/IV 12% vs 16%), residual left ventricular outflow tract gradient (16+-20 vs 16+-16 mm Hg) and repeated septal reduction procedures (12% vs 18%) in the IVS <30 mm group and IVS >=30 mm group, respectively (p=NS for all). Conclusions: The short-term results and the long-term relief of dyspnoea, residual left ventricular outflow obstruction and occurrence of repeated septal reduction procedures in patients with basal IVS >=30 mm is similar to those with IVS <30mm. However, long-term all-cause and cardiac mortality rates are worse in the >=30 mm group. (C) Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Heart
ISSN
1355-6037
e-ISSN
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Volume of the periodical
106
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
462-466
UT code for WoS article
000530040400014
EID of the result in the Scopus database
2-s2.0-85071746893