Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10402054" target="_blank" >RIV/00216208:11130/20:10402054 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/19:00521715 RIV/00216208:11310/20:10402054 RIV/00064203:_____/20:10402054
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=tOR5LKeHv5" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=tOR5LKeHv5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jcmm.14895" target="_blank" >10.1111/jcmm.14895</a>
Alternative languages
Result language
angličtina
Original language name
Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis
Original language description
WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukaemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which correlates with ETV6-RUNX1 (t(12;21)(p13;q22)) translocation and favourable prognosis in childhood leukaemia. It has a broad expression pattern in haematopoietic and in non-haematopoietic cells. However, its physiological function has been unknown. Here, we show that WBP1L negatively regulates signalling through a critical chemokine receptor CXCR4 in multiple leucocyte subsets and cell lines. We also show that WBP1L interacts with NEDD4-family ubiquitin ligases and regulates CXCR4 ubiquitination and expression. Moreover, analysis of Wbp1l-deficient mice revealed alterations in B cell development and enhanced efficiency of bone marrow cell transplantation. Collectively, our data show that WBP1L is a novel regulator of CXCR4 signalling and haematopoiesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/GBP302%2F12%2FG101" target="_blank" >GBP302/12/G101: Molecular mechanisms of signaling through leukocyte receptors their role in health and disease.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cellular and Molecular Medicine
ISSN
1582-1838
e-ISSN
—
Volume of the periodical
24
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
1980-1992
UT code for WoS article
000502870000001
EID of the result in the Scopus database
2-s2.0-85076747769