WBP1L, a transmembrane adaptor protein involved in the regulation of hematopoiesis, is controlled by CRL1 β _ TrCP ubiquitin ligases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F25%3A00617135" target="_blank" >RIV/68378050:_____/25:00617135 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/25:10500891
Result on the web
<a href="https://doi.org/10.1016/j.bbrc.2025.151337" target="_blank" >https://doi.org/10.1016/j.bbrc.2025.151337</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbrc.2025.151337" target="_blank" >10.1016/j.bbrc.2025.151337</a>
Alternative languages
Result language
angličtina
Original language name
WBP1L, a transmembrane adaptor protein involved in the regulation of hematopoiesis, is controlled by CRL1 β _ TrCP ubiquitin ligases
Original language description
WBP1L is a broadly expressed transmembrane adaptor protein involved in regulating hematopoietic stem cell function and T cell development. It interacts with NEDD4-family E3 ubiquitin ligases and regulates important chemokine receptor CXCR4. Using tandem affinity purification coupled with mass spectrometry, we identified novel WBP1L interactions with the IFN gamma receptor and the Cullin-RING ubiquitin ligases CRL1 beta _ TrCP1/2 . We found that WBP1L interaction with the IFN gamma receptor serves to downregulate proximal IFN gamma receptor signaling in female macrophages, while the interaction with CRL1 beta _ TrCP1/2 ubiquitin ligases regulates WBP1L protein levels. Disrupting this interaction, as well as inhibiting proteasome activity or neddylation, increased WBP1L protein levels, demonstrating that CRL1 beta _ TrCP1/2 ubiquitin ligases regulate WBP1L protein abundance. These data provide important insights into the mechanisms controlling WBP1L function.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochemical and Biophysical Research Communications
ISSN
0006-291X
e-ISSN
1090-2104
Volume of the periodical
749
Issue of the periodical within the volume
16 Feb
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
151337
UT code for WoS article
001407855100001
EID of the result in the Scopus database
2-s2.0-85215211279