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Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10410893" target="_blank" >RIV/00216208:11130/20:10410893 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064203:_____/20:10410893

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vC4Fv79BH8" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vC4Fv79BH8</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1084/jem.20191787" target="_blank" >10.1084/jem.20191787</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

  • Original language description

    Gene dosage is a key defining factor to understand cancer pathogenesis and progression, which requires the development of experimental models that aid better deconstruction of the disease. Here, we model an aggressive form of prostate cancer and show the unconventional association of LKB1 dosage to prostate tumorigenesis. Whereas loss of Lkb1 alone in the murine prostate epithelium was inconsequential for tumorigenesis, its combination with an oncogenic insult, illustrated by Pten heterozygosity, elicited lethal metastatic prostate cancer. Despite the low frequency of LKB1 deletion in patients, this event was significantly enriched in lung metastasis. Modeling the role of LKB1 in cellular systems revealed that the residual activity retained in a reported kinase-dead form, LKB1K78I, was sufficient to hamper tumor aggressiveness and metastatic dissemination. Our data suggest that prostate cells can function normally with low activity of LKB1, whereas its complete absence influences prostate cancer pathogenesis and dissemination. (C) 2020 Hermanova et al.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Experimental Medicine

  • ISSN

    0022-1007

  • e-ISSN

  • Volume of the periodical

    217

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    19

  • Pages from-to

  • UT code for WoS article

    000538138000011

  • EID of the result in the Scopus database

    2-s2.0-85082561362