Immune cells in carotid artery plaques: what can we learn from endarterectomy specimens?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10410916" target="_blank" >RIV/00216208:11130/20:10410916 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/20:10410916 RIV/00064203:_____/20:10410916 RIV/00023001:_____/20:00079460
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=FzR7Gn7aZz" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=FzR7Gn7aZz</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.23736/S0392-9590.19.04250-0" target="_blank" >10.23736/S0392-9590.19.04250-0</a>
Alternative languages
Result language
angličtina
Original language name
Immune cells in carotid artery plaques: what can we learn from endarterectomy specimens?
Original language description
INTRODUCTION: Endarterectomy specimens represent a unique opportunity to study atherosclerosis. This review aims to summarize the recent knowledge of atherogenesis from studies characterizing a cellular composition of carotid endarterectomy specimens. EVIDENCE ACQUISITION: A non-systematic literature review was carried out to summarize recent knowledge regarding ex vivo analysis of carotid artery plaque composition. Upon evaluation of their relevance, and elaborate forward and backward search, 95 articles were included in the review. EVIDENCE SYNTHESIS: Despite the significant advancement of in vivo imaging techniques, the stroke prediction based on carotid artery plaque morphology is not reliable. Besides analyses of plaque morphology, present studies focus on precise characterization of the different immune cell types and elucidation of their role in plaque development. Plaque content analyses revealed the presence of various immune cells in carotid artery plaques. Presence of different immune cells subpopulations can be connected to some undesirable changes in plaque stability. CONCLUSIONS: Since the destabilization of the atherosclerotic plaque is a multifactorial process, a combination of various methods should be used to characterize the unstable plaques more accurately. In this context, studies characterizing plaque content from a cellular point of view could elucidate some processes underlying the plaque progression. Together with morphological evaluation, these analyses could enable more precise assessment of plaque stability.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NV17-28103A" target="_blank" >NV17-28103A: The interplay of arterial wall and perivascular adipose tissue in the initiation of atherogenesis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Angiology
ISSN
0392-9590
e-ISSN
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Volume of the periodical
39
Issue of the periodical within the volume
1
Country of publishing house
IT - ITALY
Number of pages
13
Pages from-to
37-49
UT code for WoS article
000550122800006
EID of the result in the Scopus database
2-s2.0-85081079982