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An update on the seizures beget seizures theory

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F23%3A10465942" target="_blank" >RIV/00216208:11130/23:10465942 - isvavai.cz</a>

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=2ODFtGBy78" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=2ODFtGBy78</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/epi.17721" target="_blank" >10.1111/epi.17721</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    An update on the seizures beget seizures theory

  • Original language description

    Seizures beget seizures is a long-standing theory that proposed that seizure activity can impact on the structural and functional properties of the brain circuits in ways that contribute to epilepsy progression and the future occurrence of seizures. Originally proposed by Gowers, this theory continues to be quoted in the pathophysiology of epilepsy. We critically review the existing data and observations on the consequences of recurrent seizures on brain networks and highlight a range of factors that speak for and against the theory. The existing literature demonstrates clearly that ictal activity, especially if recurrent, induces molecular, structural, and functional changes including cell loss, connectivity reorganization, changes in neuronal behavior, metabolic alterations, etc. These changes have the potential to modify the seizure threshold, contribute to disease progression, and recruit wider areas of the epileptic network into epileptic activity. Repeated seizure activity may, thus, act as a pathological positive-feedback mechanism that increases seizure likelihood. On the other hand, the time course of self-limited epilepsies and the presence of seizure remission in two thirds of epilepsy cases and various chronic epilepsy models oppose the theory. Experimental work showed that seizures could induce neural changes that increase the seizure threshold and decrease the risk of a subsequent seizure. Due to the complex nature of epilepsies, it is wrong to restrict to seizures as the key factor responsible for disease progression. Epilepsy worsening can be attributed to the various forms of interictal epileptiform activity or underlying disease mechanisms. Although seizure activity can negatively impact brain structure and function, the &apos;seizures beget seizures&apos; theory should not be used dogmatically but with extreme caution.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30103 - Neurosciences (including psychophysiology)

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Epilepsia

  • ISSN

    0013-9580

  • e-ISSN

    1528-1167

  • Volume of the periodical

    64

  • Issue of the periodical within the volume

    Suppl. 3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    13

  • Pages from-to

    "S13"-"S24"

  • UT code for WoS article

    001041075900001

  • EID of the result in the Scopus database

    2-s2.0-85166668299