Hyperoxic ventilatory response in infants is related to nocturnal hypoxemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F24%3A10472111" target="_blank" >RIV/00216208:11130/24:10472111 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/24:10472111
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=h2dXbMV5pD" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=h2dXbMV5pD</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1183/23120541.00512-2023" target="_blank" >10.1183/23120541.00512-2023</a>
Alternative languages
Result language
angličtina
Original language name
Hyperoxic ventilatory response in infants is related to nocturnal hypoxemia
Original language description
Background The carotid bodies primarily serve as oxaemia sensors that affect tidal breathing. Their function has not been studied in infants with nocturnal hypoxaemia yet. This cross-sectional study aimed to characterise the hyperoxic ventilatory response (HVR) in infants and its relationship to nocturnal hypoxaemia.Methods The HVR was analysed in term infants aged <24 months with childhood interstitial lung disease (chILD), those with severe recurrent wheezing (wheeze), and non-respiratory controls. The HVR timing was characterised using hyperoxia response time (HRT1) and HVR magnitude was characterised by the relative change in minute ventilation between normoxia and 30-s hyperoxia (VE_dH30). Time spent with an arterial haemoglobin oxygen saturation (SpO2) <90% during overnight monitoring (t90) was estimated.Results HVR data were available for 23 infants with chILD, 24 with wheezing, and 14 control infants. A significant decrease in minute ventilation under 30 s of hyperoxia was observed in all patients. HRT1 was shorter in chILD (5.6+-1.2 s) and wheeze (5.9+-1.5 s) groups than in the controls (12.6+-5.5 s) (ANOVA p-value <0.001). VE_dH30 was increased in the chILD group (24.3+-8.0%) compared with that in the controls (14.7+-9.2%), p=0.003. T90 was abnormal in the wheeze (8.0+-5.0%) and chILD (32.7+-25.8%) groups and higher in the chILD group than in the controls (p<0.001). HRT1 negatively correlated with t90 in all groups.Conclusion Significant differences in HVR timing and magnitude were noted in the chILD, wheeze, and control groups. A relationship between nocturnal hypoxaemia and HRT1 was proposed. HVR characterisation may help identify patients with abnormal nocturnal SpO2.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
<a href="/en/project/NV19-07-00210" target="_blank" >NV19-07-00210: Primary ciliary dyskinesia: Genetic, structural and functional determinants of the disease course and prognosis.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ERJ Open Research
ISSN
2312-0541
e-ISSN
2312-0541
Volume of the periodical
10
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
00512-2023
UT code for WoS article
001159220700001
EID of the result in the Scopus database
2-s2.0-85186194087