Hyperoxic ventilatory response in infants is related to nocturnal hypoxaemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24510%2F24%3A00012376" target="_blank" >RIV/46747885:24510/24:00012376 - isvavai.cz</a>

Result on the web

<a href="https://syndication.highwire.org/content/doi/10.1183/23120541.00512-2023" target="_blank" >https://syndication.highwire.org/content/doi/10.1183/23120541.00512-2023</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/23120541.00512-2023" target="_blank" >10.1183/23120541.00512-2023</a>

Result language

angličtina

Original language name

Hyperoxic ventilatory response in infants is related to nocturnal hypoxaemia

Original language description

Background The carotid bodies primarily serve as oxaemia sensors that affect tidal breathing. Their function has not yet been studied in infants with nocturnal hypoxaemia. This cross-sectional study aimed to characterise the hyperoxic ventilatory response (HVR) in infants and its relationship to nocturnal hypoxaemia. Methods The HVR was analysed in term infants aged %6224 months with childhood interstitial lung disease (chILD), those with severe recurrent wheezing (wheeze), and nonrespiratory controls. The HVR timing was characterised using hyperoxia response time (HRT1), and HVR magnitude was characterised by the relative change in minute volume between normoxia and 30-s hyperoxia (VE_dH30). Time spent with an arterial haemoglobin oxygen saturation (SpO2) %6290% during overnight monitoring (t90) was estimated. Results HVR data were available for 23 infants with chILD, 24 wheeze and 14 control infants. A significant decrease in minute volume under 30 s of hyperoxia was observed in all patients. HRT1 was shorter in chILD (5.6±1.2 s) and wheeze (5.9±1.5 s) groups than in the controls (12.6±5.5 s) (ANOVA p%620.001). VE_dH30 was increased in the chILD group (24.3±8.0%) compared with that in the controls (14.7±9.2%) (p=0.003). t90was abnormal in the wheeze (8.0±5.0%) and chILD (32.7±25.8%) groups and higher in the chILD group than in the controls (p%620.001). HRT1 negatively correlated with t90in all groups. Conclusion Significant differences in HVR timing and magnitude were noted in the chILD, wheeze and control groups. A relationship between nocturnal hypoxaemia and HRT1 was proposed. HVR characterisation may help identify patients with abnormal nocturnal SpO2 .

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30203 - Respiratory systems

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ERJ OPEN RESEARCH

ISSN

2312-0541

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

001159220700001

EID of the result in the Scopus database

2-s2.0-85186194087