Postnatal origin of the chromosomal gains in older patients with high hyperdiploid acute lymphoblastic leukemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F24%3A10477331" target="_blank" >RIV/00216208:11130/24:10477331 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/24:10477331
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=f9lkZ-sNFU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=f9lkZ-sNFU</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2023.284128" target="_blank" >10.3324/haematol.2023.284128</a>
Alternative languages
Result language
angličtina
Original language name
Postnatal origin of the chromosomal gains in older patients with high hyperdiploid acute lymphoblastic leukemia
Original language description
We show that there is a marked difference in the percentage of BTRI/all SNVsbetween young children and older children, adolescents, and adults in HeH ALL. We interpret this asmost HeH ALL occurring in patients <10 years at diagnosis, constituting the majority of cases, have aprenatal origin of the chromosomal gains, in line with previous findings.4-13 In contrast, HeH ALLoccurring in older children, adolescents, and adults generally have a later, most likely postnatal,origin of the chromosomal gains. Notably, some cases in young children may also fall into this group,suggesting a hitherto unknown heterogeneity within HeH ALL. Considering that we have recentlyshown that the chromosomal gains occur simultaneously and very early in the leukemogenesis ofHeH ALL,15 we deem it likely that this means that also the ALL arises postnatally in these cases,although we cannot definitely exclude another, as yet hidden, primary event.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Haematologica
ISSN
0390-6078
e-ISSN
1592-8721
Volume of the periodical
109
Issue of the periodical within the volume
6
Country of publishing house
IT - ITALY
Number of pages
5
Pages from-to
1951-1955
UT code for WoS article
001250402000039
EID of the result in the Scopus database
2-s2.0-85195227110