Long-term prognosis and treatment outcomes in infantile and neonatal brain tumors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F25%3A10500077" target="_blank" >RIV/00216208:11130/25:10500077 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/25:10500077
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=b~z32Z03dz" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=b~z32Z03dz</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00381-025-06881-7" target="_blank" >10.1007/s00381-025-06881-7</a>
Alternative languages
Result language
angličtina
Original language name
Long-term prognosis and treatment outcomes in infantile and neonatal brain tumors
Original language description
PURPOSE: The specifics of biological behavior, anatomical localization, treatment, decision-making, and long-term prognosis in neonatal and infantile intracranial tumors have not been well studied. METHODS: A retrospective monocentric study of patients aged <= 12 months treated for an intracranial tumor over a 23-year period was performed. Data regarding the survival rate according to the tumor histology were evaluated in further detail. RESULTS: A total of 63 patients with a median age of 200 days at the first admission (interquartile range (IQR) = 118-301 days) were analyzed. Most tumors were supratentorial (67.7%). Overall survival according to histopathological subgroups of included tumors was the most favorable in the low-grade glioma subgroup with 1- and 3-year survival of 96% (95% confidence interval [CI] = 88.6-100%) and 88% (95% CI = 76.1-100%), while the 3-year survival for the embryonal tumors subgroup was 15% (95% CI = 4.2-53.4%). Mortality in the cohort reached 42.8% with the median time to death of 6 months (IQR = 1-12 months). CONCLUSION: Infantile and neonatal primary CNS tumors significantly vary from CNS tumors in older pediatric patients both in their localization, distribution of histopathological subtypes, and the presence of mutations specific to these tumors, providing useful therapeutic targets. Brain tumors in children under 1 year of age are scarce compared to other pediatric brain tumors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/NU23-08-00460" target="_blank" >NU23-08-00460: Advanced magnetic resonance imaging of pediatric brain tumors /PediTuMRI/</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Child's Nervous System
ISSN
0256-7040
e-ISSN
1433-0350
Volume of the periodical
41
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
251
UT code for WoS article
001541737900001
EID of the result in the Scopus database
2-s2.0-105012278125