Comparative Evaluation of Single- and Multi-Delay Arterial Spin Labeling MRI in Preterm Neonates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F25%3A10503881" target="_blank" >RIV/00216208:11130/25:10503881 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/25:10503881
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=QvKfUfIzr0" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=QvKfUfIzr0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neuroimage.2025.121511" target="_blank" >10.1016/j.neuroimage.2025.121511</a>
Alternative languages
Result language
angličtina
Original language name
Comparative Evaluation of Single- and Multi-Delay Arterial Spin Labeling MRI in Preterm Neonates
Original language description
INTRODUCTION: Preterm neonates are vulnerable to brain injuries from disrupted cerebral blood flow (CBF). Achieving high-quality MRI remains a major challenge in neonatal neuroimaging. Arterial Spin Labeling (ASL) MRI offers non-invasive, quantitative CBF assessment, but is understudied in neonates. This study evaluates the feasibility of ASL in non-sedated preterm neonates. METHODS: Preterm neonates (n=48, 25 male, post-natal age 9.74+-4.96 weeks, gestational age 28.74+-2.6 weeks) underwent T1-weighted (T1w), T2-weighted (T2w), and single- and multi-delay (3 and 7 delays) ASL scans. Image quality was rated as "good", "acceptable", or "unusable" and compared across modalities. Cortical CBF and arterial transit time (ATT) were quantified and analyzed using paired t-tests and Cohen's d. Associations with sex and age were assessed using correlation and regression models. RESULTS: Multi-delay ASL demonstrated the highest rate of acceptable images (<10% "unusable"), T2w scans outperformed T1w in quality (4.2% vs. 25% "unusable", p<0.01). Single-delay ASL yielded significantly lower cortical CBF compared to multi-delay ASL (p<0.001, d>=1.12), with sex differences observed: single-delay CBF was lower in females (p=0.035, d=0.72), and ATT was longer in males (p=0.045, d=0.60). CBF positively correlated with postmenstrual and postnatal age, especially for three-delay ASL. CONCLUSIONS: Multi-delay ASL is the favorable technique for neonatal neuroimaging based on image quality and hemodynamic measurements. Sex- and age-related hemodynamic variations underscore the importance of techniques distinguishing ATT and CBF components for improved neonatal perfusion neuroimaging. Despite frequent motion artifacts, ASL quality was comparable to structural scans. These findings support broader clinical adoption of multi-delay ASL in neonatal imaging protocols.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
NeuroImage
ISSN
1053-8119
e-ISSN
1095-9572
Volume of the periodical
321
Issue of the periodical within the volume
November
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
121511
UT code for WoS article
001603046400001
EID of the result in the Scopus database
2-s2.0-105021139597