Age-related changes in cerebral blood flow and arterial transit time in children: insights from single- and multi-delay ASL
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F25%3A10503789" target="_blank" >RIV/00216208:11130/25:10503789 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/25:10503789
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7Lu-J1wd1W" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7Lu-J1wd1W</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00234-025-03794-9" target="_blank" >10.1007/s00234-025-03794-9</a>
Alternative languages
Result language
angličtina
Original language name
Age-related changes in cerebral blood flow and arterial transit time in children: insights from single- and multi-delay ASL
Original language description
BACKGROUND: Arterial spin labeling (ASL) MRI is a non-invasive perfusion imaging technique with potential for assessing hemodynamics in children. However, understanding hemodynamic changes in developing brains remains challenging. This study investigates the impact of normal brain development on ASL-derived cerebral blood flow (CBF) and arterial transit time (ATT) in MR-negative children. METHODS: Thirty-two pediatric subjects (ages 0.7-17.9 years, mean 9.3 +- 5.3y, 19 male) with MR-negative findings were retrospectively included. Four pseudo-continuous ASL (PCASL) scans were acquired: single-delay (PLD 1525 or 2025 ms) and multi-delay (3 or 7 delays). CBF and ATT in supratentorial gray matter (GM), white matter (WM), and total-brain (TB) regions were analyzed using paired t-tests, Cohen's d, Spearman correlation, and mixed linear regression models. RESULTS: Single-delay CBF was significantly higher than 3-delay CBF in GM and WM (p < 0.001 PLD 2025 ms; p = 0.02 PLD 1525 ms). WM and TB CBF correlated negatively with age (rho=-0.56, p < 0.001), whereas GM CBF showed no significant correlation (rho=-0.03, p = 0.87); the trends differed significantly (p = 0.01). GM and TB ATT increased with age (r(2) > 0.11, p < 0.021). WM and TB CBF correlated with WM and combined WM/GM volumes (rho=-0.42, p = 0.02; rho=-0.46, p = 0.008). CONCLUSION: GM and WM exhibit distinct age-related hemodynamic patterns. WM perfusion declines with age and correlates with WM volume, while GM perfusion remains stable. The progressive increase in GM ATT highlights the need for cautious interpretation of single-delay ASL data in pediatric studies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroradiology
ISSN
0028-3940
e-ISSN
1432-1920
Volume of the periodical
67
Issue of the periodical within the volume
11
Country of publishing house
DE - GERMANY
Number of pages
14
Pages from-to
3335-3348
UT code for WoS article
001589403000001
EID of the result in the Scopus database
2-s2.0-105018214348