Kinematic alignment in total knee replacement successfully restores the native knee phenotype in the short term
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F25%3A10505300" target="_blank" >RIV/00216208:11130/25:10505300 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ZGHrn08Am1" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ZGHrn08Am1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jeo2.70561" target="_blank" >10.1002/jeo2.70561</a>
Alternative languages
Result language
angličtina
Original language name
Kinematic alignment in total knee replacement successfully restores the native knee phenotype in the short term
Original language description
PURPOSE: The goal of kinematic alignment (KA) in total knee arthroplasty (TKA) is to bring back the natural knee phenotypes. This study compared postoperative functional phenotypes in KA-TKAs against native phenotypes of healthy young Iranians, addressing the need for population-specific alignment targets. METHODS: The study analysed 300 KA-TKAs and 150 native phenotypes of healthy young Iranians. Full-limb radiographs were used to measure alignment parameters and classify phenotypes. Patient-reported outcomes were collected to assess functional recovery. The research focused on phenotype restoration, gender differences and ethnic variations in constitutional alignment. RESULTS: KA-TKA successfully restored constitutional knee phenotypes in 91.7% of patients. The top five phenotypes showed similar proportions in both TKA (52.7%) and control (54.2%) groups. Females demonstrated higher phenotype restoration rates, particularly for valgus-dominant phenotypes. The Forgotten Joint Scores at 3 months showed a significant improvement of 18% when comparing phenotype-matched patients to outliers. KA-TKA cases that failed to match the control phenotype distribution amounted to 8.3%, and these cases showed significant preoperative deformities as well as high body mass index. The research demonstrated important differences in ethnic populations since 53.7% of Iranians showed constitutional varus compared to 28.3% of Swiss individuals. CONCLUSION: The study demonstrates that KA-TKA successfully restores native knee phenotypes to most Iranian patients. The alignment targets require customization for population-specific standards together with attention to gender-specific variations. LEVEL OF EVIDENCE: Level III.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30211 - Orthopaedics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Experimental Orthopaedics
ISSN
2197-1153
e-ISSN
2197-1153
Volume of the periodical
12
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
e70561
UT code for WoS article
001614373000001
EID of the result in the Scopus database
2-s2.0-105021874523