DNA methylation age acceleration mediates the relationship between systemic inflammation and cognitive impairment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F25%3A10507272" target="_blank" >RIV/00216208:11130/25:10507272 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=86aMtGFQE5" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=86aMtGFQE5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/17501911.2025.2595905" target="_blank" >10.1080/17501911.2025.2595905</a>

Result language

angličtina

Original language name

DNA methylation age acceleration mediates the relationship between systemic inflammation and cognitive impairment

Original language description

BACKGROUND: Chronic inflammation and DNA methylation are potential mechanisms in dementia etiology. The linkage between inflammation and DNA methylation age acceleration in shaping dementia risk remains understudied. We explored the association of inflammatory cytokines with cognitive impairment and whether DNA methylation age acceleration mediates this relationship. RESEARCH DESIGN AND METHODS: Using data from the 2016 Health and Retirement Study (n = 3,346, age &gt;50), we estimate the associations between each inflammatory cytokine (interleukin-6 (IL-6), C-reactive protein (CRP), and insulin-like growth factor-1 (IGF-1)), and cognitive status, classified using the Langa-Weir method. We tested if DNA methylation age acceleration mediated the relationship between systemic inflammation and cognitive impairment, adjusting for sociodemographic, behavioral factors, chronic conditions, and cell-type proportions. RESULTS: Cognitive impairment prevalence was 16%. A doubling of IL-6 was associated with a 12% higher odds of cognitive impairment (OR = 1.12, 95% CI: 1.02-1.22), and 0.77 years of GrimAge acceleration (95% CI: 0.64-0.90). Similar associations were found for CRP and IGF-1. Mediation analysis indicated that 17.7% (95% CI: 7.0-50.9%) of the IL-6-cognitive impairment association was mediated by the GrimAge acceleration. Comparable mediated estimates were found for CRP and IGF-1. CONCLUSIONS: Systemic inflammation is associated with cognitive impairment, with suggestive evidence that this relationship is partially mediated through DNA methylation age acceleration.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30304 - Public and environmental health

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epigenomics

ISSN

1750-1911

e-ISSN

1750-192X

Volume of the periodical

17

Issue of the periodical within the volume

18

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1399-1409

UT code for WoS article

001633699300001

EID of the result in the Scopus database

2-s2.0-105024846093