Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of K(IR)2.1 ion channel expression but not that of K(v)11.1
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F11%3A10103245" target="_blank" >RIV/00216208:11140/11:10103245 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejphar.2010.10.093" target="_blank" >http://dx.doi.org/10.1016/j.ejphar.2010.10.093</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejphar.2010.10.093" target="_blank" >10.1016/j.ejphar.2010.10.093</a>
Alternative languages
Result language
angličtina
Original language name
Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of K(IR)2.1 ion channel expression but not that of K(v)11.1
Original language description
Pentamidine disrupt trafficking of two structurally different potassium channels, which can precipitate life-threatening arrhythmia. We demonstrate that a single drug can interfere in cardiac potassium channel trafficking in a subtype specific mode and that this adverse drug effect can be corrected in a channel specific manner.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Pharmacology
ISSN
0014-2999
e-ISSN
—
Volume of the periodical
652
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
96-103
UT code for WoS article
000286845500014
EID of the result in the Scopus database
—