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Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of K(IR)2.1 ion channel expression but not that of K(v)11.1

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F11%3A10103245" target="_blank" >RIV/00216208:11140/11:10103245 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.ejphar.2010.10.093" target="_blank" >http://dx.doi.org/10.1016/j.ejphar.2010.10.093</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ejphar.2010.10.093" target="_blank" >10.1016/j.ejphar.2010.10.093</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of K(IR)2.1 ion channel expression but not that of K(v)11.1

  • Original language description

    Pentamidine disrupt trafficking of two structurally different potassium channels, which can precipitate life-threatening arrhythmia. We demonstrate that a single drug can interfere in cardiac potassium channel trafficking in a subtype specific mode and that this adverse drug effect can be corrected in a channel specific manner.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Journal of Pharmacology

  • ISSN

    0014-2999

  • e-ISSN

  • Volume of the periodical

    652

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    8

  • Pages from-to

    96-103

  • UT code for WoS article

    000286845500014

  • EID of the result in the Scopus database