The anti-protozoal drug pentamidine blocks K(IR)2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F10%3A10103267" target="_blank" >RIV/00216208:11140/10:10103267 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1476-5381.2010.00658.x" target="_blank" >http://dx.doi.org/10.1111/j.1476-5381.2010.00658.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1476-5381.2010.00658.x" target="_blank" >10.1111/j.1476-5381.2010.00658.x</a>
Alternative languages
Result language
angličtina
Original language name
The anti-protozoal drug pentamidine blocks K(IR)2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel
Original language description
Pentamidine treatment may cause sudden cardiac death by provoking cardiac arrhythmias. It is known that pentamidine disrupt trafficking of hERG potassium channel. Here we demonstrate direct interaction of pentamidine with KIR2.X channel resulting in functional block of IK1 current.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British Journal of Pharmacology
ISSN
0007-1188
e-ISSN
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Volume of the periodical
159
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
1532-1541
UT code for WoS article
000275873700016
EID of the result in the Scopus database
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