Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance inTrypanosoma brucei
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F20%3A00540068" target="_blank" >RIV/60077344:_____/20:00540068 - isvavai.cz</a>
Result on the web
<a href="https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008458" target="_blank" >https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008458</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pntd.0008458" target="_blank" >10.1371/journal.pntd.0008458</a>
Alternative languages
Result language
angličtina
Original language name
Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance inTrypanosoma brucei
Original language description
Author summary Understanding mechanisms that make cells sensitive to xenobiotics (including drugs) is of great importance to both drug development and public health. For the latter, emergence of resistance is particularly important to monitor as well as to predict. Trypanosomes are a major global health burden and for several drugs resistance has emerged and is a considerable concern. Here we have examined the sensitivity to pentamidine, which is mainly mediated by an aquaglyceroporin, a surface channel. We find that the protein is highly sensitive to mutation, rendering the protein unstable, and rendering parasites resistant to pentamidine. As this also includes mutant forms recovered from patients where pentamidine treatment has failed, we suggest that the instability of aquaglyceroporin is an important contributor towards treatment failure.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30309 - Tropical medicine
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS Neglected Tropical Diseases
ISSN
1935-2735
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
26
Pages from-to
e0008458
UT code for WoS article
000552596700004
EID of the result in the Scopus database
2-s2.0-85089114743