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Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance inTrypanosoma brucei

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F20%3A00540068" target="_blank" >RIV/60077344:_____/20:00540068 - isvavai.cz</a>

  • Result on the web

    <a href="https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008458" target="_blank" >https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008458</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1371/journal.pntd.0008458" target="_blank" >10.1371/journal.pntd.0008458</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance inTrypanosoma brucei

  • Original language description

    Author summary Understanding mechanisms that make cells sensitive to xenobiotics (including drugs) is of great importance to both drug development and public health. For the latter, emergence of resistance is particularly important to monitor as well as to predict. Trypanosomes are a major global health burden and for several drugs resistance has emerged and is a considerable concern. Here we have examined the sensitivity to pentamidine, which is mainly mediated by an aquaglyceroporin, a surface channel. We find that the protein is highly sensitive to mutation, rendering the protein unstable, and rendering parasites resistant to pentamidine. As this also includes mutant forms recovered from patients where pentamidine treatment has failed, we suggest that the instability of aquaglyceroporin is an important contributor towards treatment failure.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30309 - Tropical medicine

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    PLoS Neglected Tropical Diseases

  • ISSN

    1935-2735

  • e-ISSN

  • Volume of the periodical

    14

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    26

  • Pages from-to

    e0008458

  • UT code for WoS article

    000552596700004

  • EID of the result in the Scopus database

    2-s2.0-85089114743