Evolution, function and roles in drug sensitivity of trypanosome aquaglyceroporins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F21%3A00554907" target="_blank" >RIV/60077344:_____/21:00554907 - isvavai.cz</a>
Result on the web
<a href="https://www.cambridge.org/core/journals/parasitology/article/evolution-function-and-roles-in-drug-sensitivity-of-trypanosome-aquaglyceroporins/34AF8BE79D25B40DB0EE1DC372A42EDA" target="_blank" >https://www.cambridge.org/core/journals/parasitology/article/evolution-function-and-roles-in-drug-sensitivity-of-trypanosome-aquaglyceroporins/34AF8BE79D25B40DB0EE1DC372A42EDA</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1017/S0031182021000354" target="_blank" >10.1017/S0031182021000354</a>
Alternative languages
Result language
angličtina
Original language name
Evolution, function and roles in drug sensitivity of trypanosome aquaglyceroporins
Original language description
Aquaglyceroporins (AQPs) are membrane proteins that function in osmoregulation and the uptake of low molecular weight solutes, in particular glycerol and urea. The AQP family is highly conserved, with two major subfamilies having arisen very early in prokaryote evolution and retained by eukaryotes. A complex evolutionary history indicates multiple lineage-specific expansions, losses and not uncommonly a complete loss. Consequently, the AQP family is highly evolvable and has been associated with significant events in life on Earth. In the African trypanosomes, a role for the AQP2 paralogue, in sensitivity to two chemotherapeutic agents, pentamidine and melarsoprol, is well established, albeit with the mechanisms for cell entry and resistance unclear until very recently. Here, we discuss AQP evolution, structure and mechanisms by which AQPs impact drug sensitivity, suggesting that AQP2 stability is highly sensitive to mutation while serving as the major uptake pathway for pentamidine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30310 - Parasitology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Parasitology
ISSN
0031-1820
e-ISSN
1469-8161
Volume of the periodical
148
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
1137-1142
UT code for WoS article
000674635600005
EID of the result in the Scopus database
2-s2.0-85101227484