Review of juxtaglomerular cell tumor with focus on pathobiological aspect

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F11%3A10105770" target="_blank" >RIV/00216208:11140/11:10105770 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/11:10105770

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173291/pdf/1746-1596-6-80.pdf" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173291/pdf/1746-1596-6-80.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1746-1596-6-80" target="_blank" >10.1186/1746-1596-6-80</a>

Result language

angličtina

Original language name

Review of juxtaglomerular cell tumor with focus on pathobiological aspect

Original language description

Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsuleand the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in preg

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diagnostic Pathology

ISSN

1746-1596

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

1-5

UT code for WoS article

000294808300001

EID of the result in the Scopus database

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