Juxtaglomerular cell tumor: A morphological, immunohistochemical and genetic study of six cases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10134276" target="_blank" >RIV/00216208:11140/13:10134276 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/13:10134276

Result on the web

<a href="http://dx.doi.org/10.1016/j.humpath.2012.04.006" target="_blank" >http://dx.doi.org/10.1016/j.humpath.2012.04.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.humpath.2012.04.006" target="_blank" >10.1016/j.humpath.2012.04.006</a>

Result language

angličtina

Original language name

Juxtaglomerular cell tumor: A morphological, immunohistochemical and genetic study of six cases

Original language description

Juxtaglomerular cell tumors (JGCTs) are rare tumors characterized by renin synthesis, hyperaldosteronism and hypertension. A curious immunohistochemical overlap between JGCT and gastrointestinal stromal tumor (GIST) including the expression of vimentin,CD34, CD 117, alpha-smooth muscle actin was previously reported, prompting us to further investigate JGCT and its phenotypic and molecular genetic characteristics. Virtual karyotyping showed gain of chromosomes 3, 4, 10, 13, 17 and 18 in one JGCT, and fluorescence in situ hybridization (FISH) study confirmed this multiple gain pattern. Additionally, loss of chromosome 9 was observed in four of six cases analyzed with FISH. A whole genome expression analysis revealed 415 up-regulated (including renin, and CD117) and 325 down-regulated genes between the 2 cases. The study confirmed earlier reports on the gain of chromosomes 4 and 10, and provided further evidence of up-regulation of the genes located on these 2 chromosomes. For the first

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/NT12010" target="_blank" >NT12010: Assesment of genetic changes in angiogenesis in different subtypes of renal tumours</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Human Pathology

ISSN

0046-8177

e-ISSN

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Volume of the periodical

44

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

47-54

UT code for WoS article

000312504400005

EID of the result in the Scopus database

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