Prognostic Significance of TIMP-1 in Non-small Cell Lung Cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F11%3A10106113" target="_blank" >RIV/00216208:11140/11:10106113 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/11:10106113

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Prognostic Significance of TIMP-1 in Non-small Cell Lung Cancer

Original language description

TIMP-1 (tissue inhibitor of metalloproteinases 1) regulates not only extracellular matrix catabolism but the major effect in tumor tissue is promotion of cell growth and anti-apoptotic activity. The aim of our study was to evaluate TIMP-1 plasma levels and tissue TIMP-1 mRNA expression as a prognostic marker in NSCLC patients. Methods: We studied a group of 108 patients with NSCLC who had undergone lung surgery. Quantitative estimation analysis of TIMP-1 mRNA was performed using RT real-time PCR. Quantitative estimation of plasma TIMP-1 protein was performed using ELISA. Results: There was shorter disease free interval (DFI) in NSCLC patients at stage II with a higher expression of TIMP-1 mRNA in tumor tissue (p{0.0001). We found there to be a statisticaly significant relation between TIMP-1 mRNA tumor tissue expression and DFI in SCC (p{0.0001). We also found shorter overall survival (OS) in patients at stages IIIa + IIIb + IV with a higher expression of TIMP-1 mRNA (p=0.0389). We fou

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NS10230" target="_blank" >NS10230: Rationalization of strategy of oncological treatment of radically inoperable colorectal liver metastases</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

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Volume of the periodical

31

Issue of the periodical within the volume

11

Country of publishing house

GR - GREECE

Number of pages

8

Pages from-to

4031-4038

UT code for WoS article

000297482000056

EID of the result in the Scopus database

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