Mammary and vaginal myofibroblastomas are genetically related lesions: fluorescence in situ hybridization analysis shows deletion of 13q14 region

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10124234" target="_blank" >RIV/00216208:11140/12:10124234 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/12:10124234
Result on the web
<a href="http://ac.els-cdn.com/S0046817712000366/1-s2.0-S0046817712000366-main.pdf?_tid=4a561d74-24ca-11e2-b69a-00000aacb360&acdnat=1351846382_57fa8bf31316fd40e14adcb73255a056" target="_blank" >http://ac.els-cdn.com/S0046817712000366/1-s2.0-S0046817712000366-main.pdf?_tid=4a561d74-24ca-11e2-b69a-00000aacb360&acdnat=1351846382_57fa8bf31316fd40e14adcb73255a056</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.humpath.2012.01.015" target="_blank" >10.1016/j.humpath.2012.01.015</a>

Result language
angličtina
Original language name
Mammary and vaginal myofibroblastomas are genetically related lesions: fluorescence in situ hybridization analysis shows deletion of 13q14 region
Original language description
Partial monosomy 13q, a chromosomal alteration originally reported in spindle cell lipoma, has also been documented in a few cases of mammary myofibroblastoma. Subsequently, a monoallelic loss of RB1 and FOXO1, located on 13q14, was identified in some cases of cellular angiofibroma, a benign stromal tumor of the lower female genital tract. This cytogenetic finding and the overlapping morphologic and immunohistochemical features shared by spindle cell lipoma, mammary myofibroblastoma, and cellular angiofibroma strongly suggest a histogenetic link among these tumors. Recently, we have emphasized morphologic and immunohistochemical similarities between mammary and vulvovaginal myofibroblastoma. The aim of the present study was to asses if these 2 tumors share the same chromosomal alteration. We studied the chromosome 13q14 region by fluorescence in situ hybridization analysis in a series of mammary and vaginal myofibroblastomas, with a readable signal in 7 of 13 mammary myofibroblastomas
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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