Low Frequency of HIF-1 alpha Overexpression in Germ Cell Tumors of the Testis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10134073" target="_blank" >RIV/00216208:11140/13:10134073 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/13:10134073

Result on the web

<a href="http://dx.doi.org/10.1097/PAI.0b013e31825e00b7" target="_blank" >http://dx.doi.org/10.1097/PAI.0b013e31825e00b7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/PAI.0b013e31825e00b7" target="_blank" >10.1097/PAI.0b013e31825e00b7</a>

Result language

angličtina

Original language name

Low Frequency of HIF-1 alpha Overexpression in Germ Cell Tumors of the Testis

Original language description

Cellular hypoxia is a hallmark of cancer. Hypoxia-inducible factor-1 alpha (HIF-1 alpha) and von Hippel-Lindau protein (pVHL) are the key mediators of cellular response to hypoxia. Little is known about their role in germ cell tumors of the testis. We therefore examined their status in a cohort of germ cell tumors of the testis. Thirty-six primary germ cell tumors of the testis (11 seminomas, 24 mixed germ cell tumors, and 1 case of pure intratubular germ cell neoplasia) were included in the study. HIF-1 alpha and pVHL expression were studied using immunohistochemical (IHC) methods in the tumor and adjacent benign tissue. Selected cases with a low pVHL expression were further tested for genetic alterations using polymerase chain reaction. HIF-1 alpha protein expression was not detectable in adjacent atrophic seminiferous tubules. In contrast, HIF-1 alpha was expressed in one third of the malignancies, but in a low percentage of cells (mean, 3%; range, 0% to 20%). No difference in HIF-1

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/NT12010" target="_blank" >NT12010: Assesment of genetic changes in angiogenesis in different subtypes of renal tumours</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Applied Immunohistochemistry

ISSN

1062-3345

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

165-169

UT code for WoS article

000315464500010

EID of the result in the Scopus database

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