Lurcher Mouse

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10134173" target="_blank" >RIV/00216208:11140/13:10134173 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/content/pdf/bfm%3A978-94-007-1333-8%2F1.pdf" target="_blank" >http://link.springer.com/content/pdf/bfm%3A978-94-007-1333-8%2F1.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-94-007-1333-8" target="_blank" >10.1007/978-94-007-1333-8</a>

Result language
angličtina
Original language name
Lurcher Mouse
Original language description
Lurcher mutant mice represent one of the frequently used mouse models of the olivocerebellar degeneration. It is caused by a mutation in the ?2 glutamate receptor subunit encoding gene. The gain of function mutation changes the receptor into a leaky membrane channel leading to chronic depolarization of the cells expressing the receptor. Heterozygous Lurcher mice suffer from virtually complete postnatal loss of cerebellar Purkinje cells and reduction of granule, stellate and basket cells and inferior olive neurons and relatively mild changes in the deep cerebellar nuclei. The death of Purkinje cells is a primary effect of the mutation and it shows features of apoptosis, autophagy and necrosis. Extinction of the granule, stellate and basket cells and inferior olive neurons is a target-related cell death. Lurcher mice display neurochemical and metabolic changes, abnormalities in the neurotransmitter and receptor systems, endocrine and immune abnormalities and multiple behavioral deficits.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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