Cerebellar degeneration in lurcher mice under confocal laser scanning microscope

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10134171" target="_blank" >RIV/00216208:11140/13:10134171 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/jemt.22198/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jemt.22198/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jemt.22198" target="_blank" >10.1002/jemt.22198</a>

Result language
angličtina
Original language name
Cerebellar degeneration in lurcher mice under confocal laser scanning microscope
Original language description
Lurcher mutant mice represent a natural model of genetically-determined olivocerebellar degeneration caused by a mutation in the ?2 glutamate receptor gene. They suffer from progressive postnatal loss of cerebellar Purkinje cells and a decrease of granule cells and inferior olive neurons. Their wild type littermates serve as healthy controls. A confocal laser scanning microscope was used aiming investigation the dynamics of changes in the cerebellar cortex of Lurcher and wild type mice derived from twostrains during the period of 8-21 postnatal days. Fluorescent double-staining was used to visualize mainly the Purkinje cells in cerebellar slices. In wild types, only normal Purkinje cells of round or regular drop-shaped were present, when staining intensity of other individual cell structures differed in dependence on the age of the animal. In Lurcher mutants, there were still some normal-shaped cells. Nevertheless, depending on the animal's age, a wide variety of stages of the cell de
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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